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The subjects in both models exhibited an increased severity of disease phenotypes compared with wild-type mice

A study from the International Consortium for Childhood APL evaluated a reduction in the dose of anthracyclines from 650 mg/m2 to 355 mg/m2 for standard risk and to 405 mg/m2 for high risk without a significant change in outcomes.87 As in adults, several studies have demonstrated the safety and efficacy of the combination of ATO and ATRA in children

Any references to biological activity are based on experimental data and are provided for informational and scientific context only

2025 Aug 1 [cited 2025 Sep 30];17(8):1074