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MCH-R1 antagonists what is keeping most research programs away from the clinic
Transl Psychiatry 9 , 173 (2019)
Notably, in a therapeutic combination approach, in a carbon tetrachloride-induced mouse model, combining silybin with GS-9973 (a drug that specifically inhibits SYK kinase in HSCs) produces a synergistic effect, more effectively inhibiting HSC activity, alleviating hepatic fibrosis, and preventing hepatic carcinoma
Sriram, K., Miller, D
