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Developed as a once-weekly subcutaneous injection, this investigational compound has attracted significant clinical attention for its potential role in obesity treatment and cardiometabolic health optimization

In the ventrolateral preoptic area, morphine reduces the firing rate and hyperpolarizes sleep-promoting neurons (as assessed by sensitivity to norephinephrine treatment) but has no effect on non-sleep-promoting interneurons (Wang et al., 2013)

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After homogenization, the supernatant was centrifuged and measured with a sensitive and specific ELISA according to the manufacturers instructions for TNF-, IL-10 and IL-1 (RayBiotech, Norcross, GA, USA)