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Machado ML, Arantes LP, da Silveira TL, Zamberlan DC, Cordeiro LM, Obetine FBB, da Silva AF, da Cruz IBM, Soares FAA, de Riva Oliveria P (2021) Ilex paraguariensis extract provides increased resistance against oxidative stress and protection against Amyloid beta-induced toxicity compared to caffeine in Caenorhabditis elegans

Serious: Pulmonary toxicity (e.g., pneumonitis, fibrosis), hypersensitivity reactions, and dermatological effects such as erythema and hyperpigmentation

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Glutathione metabolism in the lung: Inhibition of its synthesis leads to lamellar body and mitochondrial defects