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However, in a subsequent 24-week trial involving 536 obese participants, AOD 9604 did not achieve statistically robust, clinically meaningful weight-loss outcomes versus placebo, and the obesity-drug development program was discontinued around 2007

FDA-approved GLP-1 peptides such as semaglutide and tirzepatide have the strongest safety data, with GoodRx confirming these prescription-only medications are safe and effective when used as directed, a status consistent with the FDA's approval of tirzepatide for chronic weight management

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Scientific References For general scientific reference, researchers may consult: These databases provide access to peer-reviewed research, clinical studies, and biochemical data relevant to peptide compounds