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The safety profile of AXA1125, combined with its potential to improve mitochondrial function and reduce oxidative damage, warrants further investigation in clinical trials in ME/CFS and GWS patients
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Exercise-associated myokines such as irisin (Ciaowicz et al., 2025) and IL-6 (Mao et al., 2025) are linked to improved hepatic insulin sensitivity and mitochondrial performance, whereas catabolic signals released during sarcopenia, including myostatin, are associated with impaired hepatosteatosis and mitochondrial dysfunction (Joo and Kim, 2023)

This is a crucial warning for anyone considering treatment. VII
