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doi: 10.1038/gim.2014.177 141

Based on their biogenesis and size, EVs are classified into three main subtypes: Exos (30150 nm in diameter), microvesicles (1501000 nm in diameter), and apoptotic bodies (502000 nm in diameter) (recently reviewed [54,55,56]

The recent published work by Nordahl et al on an AAV-driven ET-1 overexpression model that was similar to the one used in our study found retinal damage using ERG (Nordahl et al, 2023)

Based on previous studies [8, 19, 20] it is conceivable that the increases in lean mass we observed for GSH + CIT in the present study could have occurred due to increases in muscle protein synthesis, and this could be linked to NO-induced increases in cGMP [19]