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Comprehensive GSH Antioxidant Function Review (PubMed, 2023) GSH as the Central Non-Enzymatic Antioxidant in Mammalian Cells A comprehensive review of reduced glutathione (GSH) published on PubMed confirmed that GSH is an essential non-enzymatic antioxidant in mammalian cells that acts directly to protect cells against free radicals and pro-oxidants, and as a cofactor for antioxidant and detoxification enzymes including glutathione peroxidases, glutathione S-transferases, and glyoxalases

Glutathione and the -glutamyl cycle The synthesis, transport and catabolism of GSH occur in a series of enzymatic steps and transports of membrane that are collectively called -glutamyl cycle (Figure 5) (74, 75)