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3, stabilized femurs in mice treated for four weeks with saline showed minimal bone deposition across the fracture site (panel A), with the residual fragments of pre-existing bone comprising most of the density seen in the CT scans

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While the more potent diuretics are associated with an increased loss of calcium and magnesium, hydrochlorothiazide (HydroDIURIL and others) and related diuretics are associated with calcium and magnesium retention

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