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Thanks to its small size and lack of charge, NO can easily diffuse through plasma membranes, but its diffusion into the RBCs is limited by transmembrane and intracellular resistances (185), as well as by the presence of an unstirred layer of solvent around the RBC (extracellular resistance) (46)
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Consistent with this, fructose and fructose-1, 6-diphosphate were found to protect against cell injury in APAP-treated rat liver slices via maintaining high ATP levels [74]
