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98 Additionally, tumor heterogeneity may contribute to ICI resistance as studies have demonstrated clonal neoantigen burden drives ICI responses and that T cell responses to sub-clonal neoantigens are blunted and may shape resistance

This intervention can increase serum IFG-1 level, decrease the level of IGF-BP-3, and elevate the molar ratio of IGF-1/IGF-BP-3 among short-stature children, but has no effect on morning serum GH secretion

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[DOI] [PMC free article] [PubMed] [Google Scholar] 20.Wang J., Yang G., Wang X., Wen Z., Shuai L., Luo J., Wang C., Sun Z., Liu R., Ge J., He X., Hua R., Wang X., Yang X., Chen W., Zhong G., Bu Z