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Further, GPx-1 / mice are more susceptible to injury in a cerebral ischemia-reperfusion model of stroke involving mid-cerebral artery (MCA) occlusion (83)

A study of 50 patients eligible for HSCT after 4-1BB-based CAR T-cell therapy reported the following results (PLAT-02 [NCT02028455] trial):[201] Patients who lost CAR T-cell function before 63 days after therapy had improved LFS if they underwent HSCT, compared with those who did not undergo HSCT ( P = .01)

Lithgow H, Johnston L, Ho FK, Celis-Morales C, Cobley J, Raastad T, Hunter AM, Lees JS, Mark PB, Quinn TJ, Gray SR