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In terms of ferroptosis, a research demonstrated that neutrophil ferroptosis in SLE patients was induced by the synergistic effect of autoantibodies and IFN-, leading to transcriptional repression factor CREM binding to GPX4 promoter and subsequent downregulation of GPX4 protein expression

[DOI] [PMC free article] [PubMed] [Google Scholar] 932.Russo L., Lumeng C.N

Starting or restarting any peptide protocol requires a physician evaluation, appropriate lab work, and a clinical rationale

However, in the presence of RDS51, zinc was found to coordinate with four histidine residues, His139, His140, His147, and His211, as well as two oxygens from RDS51