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The late George Eisenbarth, a leader in the field of T1D research, observed that the clock to T1D has started when islet antibodies are first detected. Achieving regulatory qualification of these antibodies as biomarkers will lead to better clinical trial design and more accurate identification of individuals who would likely benefit from early intervention. The specific biomarkers of interest include (Pro)-insulin autoantibody (IAA), Glutamic acid decarboxylase 65 (GAD65) autoantibody, Islet antigen 2 (IA-2) autoantibody, and Zinc transporter 8 (ZnT8) autoantibody

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