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Numerous reports substantiate that CSCs play a crucial role in driving tumor initiation, treatment resistance, recurrence, and metastasis ( Figure 3A )

Figure 1 Evidence-based effects of key nutrients After understanding the pathological connection between nutrients and OA and discovering the significant role of the metabolism-inflammation-oxidative stress network in it, this study explores key nutrients that can prevent or treat OA through evidence-based medicine and reveals the mechanisms by which they exert preventive or therapeutic effects (Table 1)

The link between diabetes and cardiovascular disease

Radioprotective agents may be useful as an adjunct to medical imaging to reduced patient morbidity and mortality due to ionizing radiation exposure