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Unlike GLP-1 agonists that reduce appetite or growth hormone peptides that stimulate lipolysis, the compound addresses fat metabolism at the enzymatic level: it removes the molecular governor that locks adipocytes into a low-energy-expenditure state, potentially restoring normal metabolic function in fat tissue where NNMT is overexpressed
The first is a 2014 Nature paper in which researchers knocked down NNMT in the fat and liver of mice
Many other treatments are restricted to the science by NICE
