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591 Additionally, another Keap1-Nrf2 PPI inhibitor 74 , which combined conformational features significantly similar to the Keap1-Nrf2 ETGE complex, revealed the unique inhibition mechanism and provided an innovative strategy for the development of new Keap1-Nrf2 PPI inhibitors

Heterogeneity of genomic evolution and mutational profiles in multiple myeloma

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This can result in: Importantly, neurological damage may occur independently of hematological abnormalities, indicating that different tissues exhibit distinct sensitivities to disrupted B12-dependent pathways