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Description
Lactate enters cells through monocarboxylate transporters (MCTs) on the cell membrane or via GPR81 receptor-mediated signaling pathways [14]
NREMS bout duration was not affected by treatment (not significant
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The underlying mechanism(s) linking reduced IGF-1 signaling to improved mammalian lifespan is thought to involve improved stress defenses and lower risk for proliferative diseases 9,10,11 , though the reason for sex differences in this response remains unresolved
