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The manufacturer needs to closely comply with all the regulatory requirements of the TGA right from the pre-approval phase till the post-marketing phase
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( B and E ) Comparisons between measurements of demyelination in CPZ0 mice with other groups are all significant and not annotated on the plots

It is still important because it must be taken in context with other proteins in the body, such as Sex Hormone Binding Globulin (SHBG) which binds to testosterone preventing it from becoming bioavailable
