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Steady-state kinetics were measured using a pyrophosphate assay for the apo and AdoCbl-bound dark/light states of the Ab DPcob protein, as well as the truncated DGC domain only (Fig
Using a mouse model, they showed that these drugs can increase the amount of Herceptin, a large monoclonal antibody used to treat lung and breast cancers, crossing the BBB and increase its anti-tumour effect in the brain
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