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F-box protein F-box/LRR-repeat protein 2 (FBXL2), a receptor subunit of SCF (SKP1, CUL1, F-box protein) E3 ubiquitin ligase complexes, binds to IP 3 R3 and promotes IP 3 R3 ubiquitination and degradation, limiting ER-to-mitochondria Ca 2+ transfer and attenuating apoptosis

Treatment with silymarin considerably reduces the generation of MDA-DNA adducts and hepatocellular carcinoma serum markers such as alpha-fetoprotein, carcinoembryonic antigen, aminotransferase, alkaline phosphatase, lactate dehydrogenase, gamma-glutamyltransferase and 5-nucleotidase (38)

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2012;22(Suppl 7):S5S10