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This pathway can absorb approximately 1.52 micrograms per meal , making it efficient for dietary B12 but limited for high-dose supplementation

Jackson AA, Badaloo AV, Forrester T, Hibbert JM, Persaud C: Urinary excretion of 5-oxoproline (pyroglutamic aciduria) as an index of glycine insufficiency in normal man

Since the primary mode of magnesium excretion is through the kidneys, any form of renal impairment may result in elevated serum magnesium levels and concomitant magnesium toxicity

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