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The dosage selected for research is important, but the dosage of the drug taken by the human body is difficult to convert into the concentration in vitro , which involves the rate of absorption and metabolism ( in vitro were 10 M ( Moreover, we found that only atorvastatin induces ferroptosis, while lovastatin, pravastatin, or rosuvastatin did not

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In turn, inflammatory cytokines increase Ca + influx into cells via MAPK, PLC (phospholipase C), and NF-B, establishing a positive feedback loop

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