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Beneficial effects of Oridonin on myocardial ischemia/reperfusion injury: insight gained by metabolomic approaches

Experimental evidence includes: GPX4-knockout mice show 3-fold larger infarcts with lipid peroxide accumulation in high-OXPHOS regions, while ferroptosis inhibitors (e.g., ferrostatin-1) reduce neuronal loss by 60% in MCAO models [163, 165]

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Out of 23 participants in the L-carnitine + synbiotic group, 19 (82.6%) experienced optimal amelioration in body weight post-intervention, defined as the median of weight reduction in the studied population (2.45 kg), while only 5 of the 22 participants (22.7%) in the L-carnitine + placebo group experienced the expected weight loss