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Another FDA-approved IONPs, Feraheme (ferumoxytol), an IONP-based drug, has been sanctioned for the treatment of iron deficiency anemia in patients with chronic kidney disease or patients who do not tolerate oral iron supplementation ( A concerning issue is the biodistribution of IONPs, which is influenced by various factors such as their size, shape, surface coating, and charge, as well as the dose and route of administration [reviewed in (152)]

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