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R 2 is H, C 1 -C 4 alkyl, or C 2 -C 4 alkenyl

Furthermore, clinical and preclinical studies support their role in slowing cognitive decline in Alzheimers disease and reducing dopaminergic neuronal loss in Parkinsons disease [58,59]

This metabolic plasticity not only enhances the survival of cancer cells under extreme conditions such as hypoxia and nutrient deprivation but also provides a critical foundation for therapeutic evasion and the acquisition of drug-resistant phenotypes [13]

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