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In this study the nanoparticles were prepared to demonstrate the effect of decreasing the particle size on the efficacy of the bioactive fractions related to their wound healing activity, together with the selection of chitosan as vehicle to load the bioactive fraction and its effect on the improvement of the wound healing activity, as it could play a role being iteslf a wound healer [25]

Decreased water exchange rate across blood-brain barrier in hereditary cerebral small vessel disease

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& Thome, J