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Instead, its activity is believed to be mediated via adipocyte-specific signaling cascades, which gives the fragment a uniquely narrow pharmacological footprint for a peptide of its molecular size and makes it attractive to investigators who want clean lipolytic readouts
B12 stores deplete gradually over several years
Experiments often involve rodent or cell-based systems and measure metabolic flux, markers in adipose and muscle tissues, and transcription patterns affected by NNMT activity
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