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Semax, an analogue of adrenocorticotropin (4-10), binds specifically and increases levels of brain-derived neurotrophic factor protein in rat basal forebrain

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In addition to depleting intrahepatic GSH, APAP seems to decrease the activity of anti-oxidant enzymes (SOD, CAT, GPx), as well as of enzymes involved in glutathione redox cycling (glutathione reductase, GR), utilization (glutathione S-transferase, GST) and synthesis (gamma-glutamylcysteine synthetase) (237)

Not only is enzymatic activity altered, but the ratio between reduced glutathione and oxidized glutathione is also affected [38]