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Despite wide dose ranges tested (6 g/kg to 20 mg/kg), multiple administration routes (intramuscular, intraperitoneal, intravenous, oral), and varied dosing frequencies across numerous animal models, no acute lethal dose has been identified
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Frequency depends on dysplasia level (tissue changes): no dysplasia requires endoscopy every 3-5 years

Ivermectin: pharmacology and application in dermatology