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235, 236 In addition, a decrease in the sensitivity of cancer cells to the cytostatic/cytotoxic effects of CDDP has been associated with the upregulation of microRNAs that target the major oncosuppressive factor phosphatase and tensin homolog (PTEN), such as miR-130a and miR-93, 240, 241 and ERCC1, like miR-138, 237 as well as with the downregulation of microRNAs that normally limit the expression of cell cycle-associated proteins such as let-7b

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Subtoxic oxidative stress induces senescence in retinal pigment epithelial cells via TGF-beta release