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The FDA does not conduct clinical trials or attempt to discover new treatments, but rather requires companies or other entities to fund marketing approvals

Davidovich, N

Seeley, E

Furthermore, excessive lipid deposition further aggravates tissue damage by promoting the production of reactive oxygen species (ROS) and a series of pathological changes, such as the peroxidation of cells themselves, the release of pro-inflammatory factors and the infiltration of inflammatory cells, damaged hepatocytes activate the nuclear factor kappa-B (NF-B) pathway, thus inducing the production of proinflammatory cytokine tumor necrosis factor- (TNF-) and interleukin-1/-6 (IL-1, IL-6) (Xiao et al., 2020)