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Cost, manufacturing, reproducibility Synthesising D-retro-inverso peptides with high purity is non-trivial

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During the last two decades, many studies have searched for the potential therapeutic strategies for treatment or preventing detrimental consequences of hypoxia 3
72 The prolonged biodegradation span of up to 3 years and its water insolubility may be points of concern regarding the long-term safety of PCL, particularly due to its inherent lack of antimicrobial properties