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The key histological abnormalities of AD include necrosis and apoptosis of VSMCs, fracture of elastic fibers, and degradation of extracellular matrix (ECM) (73).The thrombi formed within the false lumen indicates the presence of continued inflammation under the condition of atherosclerosis and chronic inflammation, and the higher risk of rupture in patients with inflammatory diseases demonstrates the importance of inflammation in AD (74)

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Gorshkov A, Purvinsh L, Brodskaia A, Vasin A (2022) Exosomes as natural nanocarriers for RNA-based therapy and prophylaxis