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TGR inhibitors target a reduced form of TGR Next, we investigated if the TGR redox state affects the binding and activity of the inhibitors
In type 1 sequences the Cys residues are exclusively arranged in Cys-Xaa-Cys motifs (Xaa represents another amino acid) in both the N- and C-terminus, while type 2 have Cys-Cys, Cys-Xaa-Xaa-Cys, and Cys-Xaa-Cys sequences in the N-terminal domain and Cys-Xaa-Cys in the C-terminal domain
To date, an aging atlas of the whole organ has been profiled in mice
Rights and permissions About this article Cite this article Kahn, S.E., Buse, J.B
