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Effect of mecobalamin on diabetic neuropathies: Beijing Methycobal Clinical Trial Collaborative Group

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However, caution must be exercised in the use of fluoride to treat OP, as excessive fluorine intake can lead to decreased bone strength and toughness, increased insulin resistance, elevated inflammatory factor levels, and disturbances of lipid metabolism, all of which can lead to adverse events (de Cssia Alves Nunes et al., 2016

Casein is chosen due to its low cost and high availability (62)
