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Upon bile acid activation, hepatic FXR induces expression of small heterodimer partner (SHP), which suppresses CYP7A1 and CYP8B1 gene transcription, thereby reducing bile acid synthesis (68)

Among EMT-related miRNAs, miR-34c-5p directly targets FOSL1 (Fra-1) to reverse silica-induced EMT, restoring E-cadherin expression while suppressing vimentin and reducing cell proliferation and migration ( In the context of circRNAs, several molecules have been identified as upstream modulators of EMT and fibroblast activation