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5 Clinical translation opportunities and challenges 5.1 Exercise mimetics Recent years have witnessed growing interest in bioactive oral compounds that mimic or amplify exercise benefits, termed exercise mimetics or exercise pills. These compounds aim to stimulate muscle adaptations akin to exercise, yet their capacity to fully replicate exercise effects remains contentious

Additionally, sulfasalazine (SAS) can induce ferroptosis in BC cells, particularly in cells with low ER expression

Metabolomics refers to the measurement of intermediary and final products of metabolic pathways during physiological and pathophysiological processes (see Figure 3) [25]

doi: 10.1371/journal.pone.0056888 97 ZhangYZLiYY
