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The ACSL4/GPX4 ratio has been shown to predict ferroptosis in MS lesions, and 4-HNE adducts indicate lipid peroxidation in the AD hippocampus (Butterfield et al., 2010

[DOI] [PMC free article] [PubMed] [Google Scholar] Shih, Y

Our results indicated that TG2 interferes with GST fusion protein interactions

HRD1 therefore seems to be a potential new target for ameliorating cirrhosis-induced liver oxidative stress and preventing progression of the disease
