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Lipid oversupply to the mitochondria exceeds the capacity of the enzymatic pathways, leading to an imbalance between -oxidation and the Krebs cycle

Transplantation of gut microbiota from normal healthy rats into hypertensive rats decreased sympathetic activation and inflammation in the paraventricular nucleus, resulting in lowered blood pressure indicating that gut microbial metabolism may affect sympathetic drive via gutsympathetic neural connections or by inducing neuroinflammation, thereby influencing blood pressure [36]

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