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Messina, A
In addition, a persistent inflammatory state triggers a sharp increase in oxidative stress levels in thyroid tissue and the production of excessive reactive oxygen species (ROS)
Glutathione cho c th
Additional physiological functions attributed to heparanase include the transcriptional upregulation and expression of the pro-inflammatory cytokines, TNF-, interleukin (IL)-1, IL-6, as well as the activation of the innate immunity system, exosome formation, and positive regulation of autophagy (300)
