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CFS/FM/ME can be a debilitating condition affecting around 3% of the population The condition is generally misunderstood, however, symptoms are very similar to those seen with an absolute deficiency of vitamin B12 The condition is characterized by Paradoxical B12 deficiency Studies on over 700 individuals have shown all have functional B2 deficiency Functional B2 deficiency results in functional B12 deficiency

doi: 10.1016/j.bpj.2011.11.4006