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5B), confirming reduced 11-OH-THC production in FABP1-KO hepatocytes
In stark contrast, the leukemic Nalm6 cell line was very sensitive to L-BSO and to very low concentrations of FA (Fig
On the other hand, treatment with NMDA showed only a non-significant tendency to decrease intracellular GSH (Figure 4B), which was also prevented by STW3-VI
Thus, in the canonical GPX4-regulated ferroptotic pathway, the inhibition of two cellular components, GPX4 and system XC cystine/glutamate antiporter, by RSL3 and erastin, respectively, triggers ferroptotic cell death (7,23)
