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In the renin-angiotensin system, some peptides can inhibit the release renin, an enzyme catalyzing the conversion of angiotensinogen to angiotensin I (Harnedy and FitzGerald, 2013), while some peptides can inactivate ACE, an enzyme that can catalyze the conversion of angiotensin I to angiotensin II and also the degradation of bradykinin, an enzyme that can relax blood vessels, to inactive peptide fragments in kinin-arginine-nitric oxide system (Siltari et al., 2016

In breast cancer, aryl hydrocarbon receptor (AhR) acts as a ligand-dependent bridge between the stimulator of the interferon gene (STING) and the CUL4B/RBX1 E3 ligase complex, promoting STING degradation and facilitating tumor progression [13]

When the sensory nerve is stimulated, it conducts the signal to the central nervous system, activating the efferent parasympathetic and sympathetic nerves that innervate the acini of the lacrimal gland [47]

TABLE 4 Application of bee venom in wound healing