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613 A more recent study identified a bioactive metabolite of sebaleic acid, 6( E ),8( Z )-5-oxo-ODE, which stimulated calcium mobilization in human neutrophils and induced desensitization to 5-oxo-ETE (5-KETE), but not LTB 4 , indicating that this effect was mediated by the oxo-eicosanoid receptor (GPR170)

ALOX15 KD did, however, lead to decreased extracellular GSSG ( P = 0.021), with marginal but insignificant increases in extracellular GSH:GSSG ( P = 0.083)

Compound 21 is a modified derivative of YIL781, a commercially available ghrelin receptor antagonist

[DOI] [PubMed] [Google Scholar] 218.Van Den Bosch L., Vandenberghe W., Klaassen H., Van Houtte E., Robberecht W