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This reduced bone response to the stimulatory effects of GH via IGF-1 has been linked to decreased VEGF expression and diminished vascularization in the primary ossification zone of rats with renal insufficiency.102 In the same way, intensive treadmill exercise improves linear bone growth in a rat model of renal insufficiency (5/6Nx)

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We then compared how many splicing events were altered by FUS/TLS depletion and if they were rescued by mutant FUS/TLS