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Filters for grade A mechanism, indicating peer-reviewed publications to target relevant mechanisms in humans, and grade A trial or case data, indicated by two or more peer-reviewed publications describing benefit in well-designed placebo-controlled human trials, or one or more peer-reviewed publications reporting benefits in validated diagnoses were applied for inclusion in our review

COA data can support batch identity, purity, and analytical traceability, but it cannot convert a research chemical into an approved drug, supplement, cosmetic ingredient, therapeutic material, or veterinary product

A principal obstacle pertains to the heterogeneity in the composition of botanical extracts, as disparities in plant provenance, extraction methodologies, and standardization protocols culminate in variable concentrations of bioactive constituents