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Subsequently, a cascade of reactions ensues, which includes the interaction of superoxides with nitric oxide (NO) to yield peroxynitrite (ONOO ) and the conversion of H 2 O 2 into water, eventually leading to the generation of hydroxyl radicals ( A significant source of ROS emerges from the end substrate of the respiratory chain, situated within the inner mitochondrial membrane

Human Reproduction , 33(3), 494502

This means that, as your hair's pigment-producing melanocytes die off (they typically live about 3 to 5 years), there aren't enough active stem cells to replace them all and some hair starts to grow in without pigment, i.e

If you have sensitive skin or specific skin concerns, performing a patch test before full application is recommended.