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For example, deferiprone (DFP) and PBT2 have been shown to increase endothelial tight junction protein expression in AD models, reduce vascular leakage, and improve BBB integrity, suggesting an indirect BBB-protective potential (Ayton et al., 2025)

Journal of the American Veterinary Medical Association 190: 14171421

It affects the brain via the bloodstream and aids in the consolidation and retrieval of memories

(2019) found that these untreated patients had significantly less diverse gut bacteria (lower -diversity) compared to healthy individuals
