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Vitamin B12 (cobalamin) is essential for: Red blood cell production DNA synthesis Nervous system function Energy metabolism B12 deficiency is common in the UK, especially among people following vegetarian or vegan diets, those over 50, or individuals with gastrointestinal conditions affecting absorption (e.g., coeliac disease, Crohns, IBS)

Notably, no effect of high-dose folic acid (5 mg/day) for 3-months on blood MMA concentrations was observed in a cohort of middle-aged individuals (82)